Monocyte and macrophage plasticity in tissue repair and regeneration.

  title={Monocyte and macrophage plasticity in tissue repair and regeneration.},
  author={Amitava Das and Mithun Sinha and Soma Datta and Motaz Abas and Scott Chaffee and Chandan K. Sen and Sashwati Roy},
  journal={The American journal of pathology},
  volume={185 10},
Heterogeneity and high versatility are the characteristic features of the cells of monocyte-macrophage lineage. The mononuclear phagocyte system, derived from the bone marrow progenitor cells, is primarily composed of monocytes, macrophages, and dendritic cells. In regenerative tissues, a central role of monocyte-derived macrophages and paracrine factors secreted by these cells is indisputable. Macrophages are highly plastic cells. On the basis of environmental cues and molecular mediators… CONTINUE READING
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