Monocyte and lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in clinical management.

@article{Tolomeo2003MonocyteAL,
  title={Monocyte and lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in clinical management.},
  author={Manlio Tolomeo and Paola Di Carlo and Vincenzo Abbadessa and Lucina Titone and Silvana Miceli and Eleonora Barbusca and Giuliana Cannizzo and Salvatrice Mancuso and Serenella Arista and Francesco Scarlata},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={36 12},
  pages={1533-8}
}
This study evaluated the level of susceptibility of monocytes and lymphocytes to spontaneously induced and CH11-induced apoptosis in 16 patients with Brucella infection. The expression of some immunological and apoptotic markers was evaluated. Before therapy, monocytes showed a high level of resistance to spontaneously induced or CH11-induced apoptosis in all patients. In patients with acute infection, this resistance persisted for 10-20 days after treatment was initiated, then decreased; in… CONTINUE READING

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The role of APO1mediated apoptosis in the immune system

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