Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation.

@article{Peterson2005MonocyteAT,
  title={Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation.},
  author={Mark D Peterson and Rongyu Jin and Sharon J. Hyduk and Pascal Duchesneau and Myron I Cybulsky and Thomas K Waddell},
  journal={Journal of immunology},
  year={2005},
  volume={174 12},
  pages={8072-81}
}
Monocytes are the predominant inflammatory cell recruited to xenografts and participate in delayed xenograft rejection. In contrast to allogeneic leukocytes that require up-regulation of endothelial adhesion molecules to adhere and emigrate into effector tissues, we demonstrate that human monocytes adhere rapidly to unstimulated xenogeneic endothelial cells. The major xenoantigen galactosealpha(1,3)galactosebeta(1,4)GlcNAc-R (alpha-gal) is abundantly expressed on xenogeneic endothelium. We have… CONTINUE READING

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