Monocyte adhesion to mesangial matrix modulates cytokine and metalloproteinase production.

@article{Chana2003MonocyteAT,
  title={Monocyte adhesion to mesangial matrix modulates cytokine and metalloproteinase production.},
  author={Ravinder S Chana and John Martin and Enam U Rahman and David C. Wheeler},
  journal={Kidney international},
  year={2003},
  volume={63 3},
  pages={889-98}
}
BACKGROUND Monocytes migrate into the glomerular mesangium during acute inflammatory renal disease, differentiate into macrophages, and may play a key role in the development and progression of glomerular scarring. Treatment strategies that inhibit monocyte infiltration ameliorate glomerular injury in animal models. Mesangial matrix contains several potential monocyte-binding domains that may contribute to monocyte entrapment and modulate cell activation. METHODS Adhesion of peripheral blood… CONTINUE READING

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