Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.

@article{McGilvray2002MonocyteAA,
  title={Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.},
  author={Ian D. McGilvray and Vance Tsai and John C. Marshall and Alan P. B. Dackiw and Ori D. Rotstein},
  journal={Shock},
  year={2002},
  volume={18 1},
  pages={
          51-7
        }
}
The expression of tissue factor (TF) by monocytes that have transmigrated across the endothelium to sites of extravascular inflammation acts both to focus and amplify the inflammatory response. Because clustering of the integrins responsible for endothelial adhesion and transmigration induces tyrosine phosphorylation and activation of the mitogen-activated protein (MAP) kinases, we postulated that transmigration might lead to monocyte activation and TF production. Monocytes were migrated across… CONTINUE READING

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