Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles.

@article{SzabTaylor2017MonocyteAD,
  title={Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles.},
  author={Katalin {\'E}. Szab{\'o}-Taylor and Eszter {\'A} T{\'o}th and A. Balogh and Barbara W S{\'o}dar and L K{\'a}d{\'a}r and Krisztina P{\'a}l{\'o}czi and N{\'o}ra Fekete and Andrea N{\'e}meth and Xabier Osteikoetxea and Krisztina V. Vukman and Marcsilla Holub and {\'E}va P{\'a}llinger and Gy Nagy and Paul G. Winyard and Edit Ir{\'e}n Buz{\'a}s},
  journal={Free radical biology & medicine},
  year={2017},
  volume={108},
  pages={56-65}
}
The redox state of cellular exofacial molecules is reflected by the amount of available thiols. Furthermore, surface thiols can be considered as indicators of immune cell activation. One group of thiol containing proteins, peroxiredoxins, in particular, have been associated with inflammation. In this study, we assessed surface thiols of the U937 and Thp1 monocyte cell lines and primary monocytes in vitro upon inflammatory stimulation by irreversibly labelling the cells with a fluorescent… CONTINUE READING
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Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins

  • K.É. Szabó, K. Line, P. Eggleton, J. A. Littlechild, P. G. Winyard
  • thioredoxins, thioredoxin reductases…
  • 2017
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