Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells.

@article{Lam2005MonocrotalinePT,
  title={Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells.},
  author={Michael W. Lam{\'e} and A. Daniel Jones and Dennis W. Wilson and Hank J Segall},
  journal={Proteomics},
  year={2005},
  volume={5 17},
  pages={4398-413}
}
A single injection of monocrotaline produces a pulmonary insult in rats with a phenotype similar to human primary pulmonary hypertension. Although extensively used as a model, the mechanism(s) by which this chemical insult mimics a condition with genetic and environmental links remains an enigma, although formation of protein adducts has been implicated. Monocrotaline (MCT) is non-toxic and must undergo hepatic dehydrogenation to the soft electrophile monocrotaline pyrrole as prerequisite to… CONTINUE READING

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