Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

  title={Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease},
  author={Kung-Chao Chang and Yu-Chu Wang and L Hung and Wan-Ting Huang and J Tsou and Dan M. Jones and Hsiang-Lin Song and Yu-Min Yeh and Lin-Yuan Kao and L Jeffrey Medeiros},
  journal={Modern Pathology},
Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor α (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20… CONTINUE READING
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