Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.

@article{Michetti1992MonoclonalSI,
  title={Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.},
  author={P Michetti and Michael J. Mahan and James M Slauch and John J Mekalanos and Marian R. Neutra},
  journal={Infection and immunity},
  year={1992},
  volume={60 5},
  pages={1786-92}
}
Hybridomas producing monoclonal immunoglobulin A (IgA) antibodies against Salmonella typhimurium were generated by mucosal immunization of BALB/c mice with attenuated strains of S. typhimurium and subsequent fusion of Peyer's patch lymphoblasts with myeloma cells. To test the role of secretory IgA (sIgA) in protection against Salmonella sp., we analyzed in detail the protective capacity of a monoclonal IgA, Sal4, produced in polymeric as well as monomeric forms, that is directed against a… CONTINUE READING
90 Citations
12 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

The structure and function of human IgA

  • M. A. Kerr
  • Biochem. J. 271:285-296
  • 1990

Infectious diarrhea, p. 1191-1232

  • S. L. Gorbach
  • 1989

Similar Papers

Loading similar papers…