Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.

@article{Michetti1992MonoclonalSI,
  title={Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.},
  author={P. Michetti and M. Mahan and J. Slauch and J. Mekalanos and M. Neutra},
  journal={Infection and immunity},
  year={1992},
  volume={60 5},
  pages={
          1786-92
        }
}
  • P. Michetti, M. Mahan, +2 authors M. Neutra
  • Published 1992
  • Biology, Medicine
  • Infection and immunity
  • Hybridomas producing monoclonal immunoglobulin A (IgA) antibodies against Salmonella typhimurium were generated by mucosal immunization of BALB/c mice with attenuated strains of S. typhimurium and subsequent fusion of Peyer's patch lymphoblasts with myeloma cells. To test the role of secretory IgA (sIgA) in protection against Salmonella sp., we analyzed in detail the protective capacity of a monoclonal IgA, Sal4, produced in polymeric as well as monomeric forms, that is directed against a… CONTINUE READING
    Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies
    • 1
    • Highly Influenced
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 12 REFERENCES
    Intestinal colonization and virulence of Salmonella in mice.
    • 152
    • Open Access
    Overview of the mucosal immune system.
    • 274
    • Open Access
    THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE
    • 606
    • Open Access
    Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer
    • 206
    • Open Access
    The structure and function of human IgA.
    • 508
    • Open Access
    Lymphoepithelial interactions in the mucosal immune system.
    • 112
    • Open Access
    Summary of an international workshop on typhoid fever.
    • 375
    • Open Access