Monoclonal murine anti-DNA antibody interacts with living mononuclear cells.

@article{Okudaira1987MonoclonalMA,
  title={Monoclonal murine anti-DNA antibody interacts with living mononuclear cells.},
  author={Kazuho Okudaira and Hirohisa Yoshizawa and Ralph Williams},
  journal={Arthritis and rheumatism},
  year={1987},
  volume={30 6},
  pages={669-78}
}
A monoclonal mouse antibody, 4-B-5, that reacted with both single-stranded DNA (ssDNA) and double-stranded DNA showed direct reactivity and cell association with mouse thymocytes, as well as peripheral blood mononuclear cells. Absorption of 4-B-5 with peripheral blood mononuclear cells or with mouse thymocytes markedly reduced reactivity with both ssDNA and double-stranded DNA. However, treatment of mouse thymocytes or human T cells with DNase completely eliminated monoclonal anti-DNA… CONTINUE READING