Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria.

@article{Bos1996MonoclonalIA,
  title={Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria.},
  author={Nicolaas A. Bos and Judy C. A. M. Bun and Sicco H. Popma and E R Cebra and Gerrit Jan Deenen and Maarten J F van der Cammen and Frans G. M. Kroese and John J. Cebra},
  journal={Infection and immunity},
  year={1996},
  volume={64 2},
  pages={616-23}
}
We transferred peritoneal cells from BALB/c mice into C.B17 scid/scid mice. Six to eight months after injection, only cells with the B1 phenotype were retained in the spleens and peritoneal cavities of these mice. The lamina propria of the intestine contained many peritoneal, donor-derived, immunoglobulin A (IgA)-producing cells. The mesenteric lymph nodes of these mice were found to be a major site of proliferation and generation of IgA plasmablasts. We established eight IgA-producing… CONTINUE READING
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