Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins.

@article{Hrkk1999MonoclonalAS,
  title={Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins.},
  author={Sohvi H{\"o}rkk{\"o} and David A. Bird and Eric Miller and Hiroyuki Itabe and Norbert Leitinger and Ganesamoorthy G. Subbanagounder and Judith A. Berliner and P. A. Friedman and Edward A. Dennis and Linda K. Curtiss and Wulf Palinski and Joseph L. Witztum},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 1},
  pages={117-28}
}
We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies). We now demonstrate that those EO- autoantibodies that were originally selected for binding to copper-oxidized low-density lipoproteins (CuOx-LDL), also bound both to the oxidized protein and to the oxidized lipid moieties of CuOx-LDL. The same EO- autoantibodies showed specific binding to products of oxidized 1-palmitoyl-2… CONTINUE READING
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