Monoclonal antibody to tumor necrosis factor-alpha attenuates hemodynamic dysfunction secondary to intestinal ischemia/reperfusion in rats.

@article{Yao1996MonoclonalAT,
  title={Monoclonal antibody to tumor necrosis factor-alpha attenuates hemodynamic dysfunction secondary to intestinal ischemia/reperfusion in rats.},
  author={Yicheng Yao and Soheyl Bahrami and Heinz Redl and G{\"u}nther Schlag},
  journal={Critical care medicine},
  year={1996},
  volume={24 9},
  pages={
          1547-53
        }
}
OBJECTIVE To evaluate the effects of monoclonal antibody to tumor necrosis factor (TNF)-alpha on the hemodynamic alterations and survival rate in rats subjected to intestinal ischemia/reperfusion. DESIGN Prospective, randomized study. SETTING Animal laboratory of an institute for research in traumatology. SUBJECTS Male Sprague-Dawley rats, weighing 430 to 460 g. INTERVENTIONS Anesthetized rats underwent 75 mins of superior mesenteric artery occlusion followed by 6 hrs of reperfusion… CONTINUE READING
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