Monoclonal antibody to endotoxin attenuates hemorrhage-induced lung injury and mortality in rats.

@article{Bahrami1997MonoclonalAT,
  title={Monoclonal antibody to endotoxin attenuates hemorrhage-induced lung injury and mortality in rats.},
  author={Soheyl Bahrami and Y. M. Yao and G Leichtfried and Heinz Redl and G{\"u}nther Schlag and Franco E di Padova},
  journal={Critical care medicine},
  year={1997},
  volume={25 6},
  pages={1030-6}
}
OBJECTIVES To determine the possible role of enteric bacteria-derived endotoxin in the pathogenesis of the lung injury and mortality in rats following hemorrhagic shock and resuscitation. DESIGN Prospective, randomized study. SETTING Animal laboratory of an institute for research traumatology. SUBJECTS Male Sprague-Dawley rats, weighing 450 to 480 g. INTERVENTIONS Anesthetized rats were subjected to a prolonged hemorrhagic shock (mean arterial pressure of 30 to 35 mm Hg for 180 mins… CONTINUE READING

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