Monoclonal antibody to CD4+ T cells abrogates genetic resistance to Haemonchus contortus in sheep.

@article{Gill1993MonoclonalAT,
  title={Monoclonal antibody to CD4+ T cells abrogates genetic resistance to Haemonchus contortus in sheep.},
  author={Harsharnjit Singh Gill and Dennis L. Watson and Malcolm R. Brandon},
  journal={Immunology},
  year={1993},
  volume={78 1},
  pages={43-9}
}
The roles of CD4+ and CD8+ T cells in genetically determined resistance of sheep to Haemonchus contortus (a natural host-parasite relationship) was investigated by selectively depleting genetically resistant merino lambs of their CD4+ or CD8+ T cells by treatment with mouse monoclonal antibody (mAb) specific for the appropriate determinant before and during challenge infection. Administration of anti-CD4 mAb to genetically resistant lambs completely abrogated their expression of genetic… CONTINUE READING