Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.

@article{Jin2009MonoclonalAT,
  title={Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.},
  author={Liqing Jin and Erwin M. Lee and Hayley S. Ramshaw and Samantha J. Busfield and Armando G Peoppl and Lucy J Wilkinson and Mark A. Guthridge and Daniel T Thomas and Emma F. Barry and Andrew M Boyd and David P. Gearing and Gino Vairo and Angel F Lopez and John E Dick and Richard B. Lock},
  journal={Cell stem cell},
  year={2009},
  volume={5 1},
  pages={31-42}
}
Leukemia stem cells (LSCs) initiate and sustain the acute myeloid leukemia (AML) clonal hierarchy and possess biological properties rendering them resistant to conventional chemotherapy. The poor survival of AML patients raises expectations that LSC-targeted therapies might achieve durable remissions. We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of… CONTINUE READING
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