Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis.

Abstract

Macrophage responses are regulated by multiple secreted factors as well as by cell surface receptors, including the inhibitory signals resulting from ligation of myeloid CD200 receptors (CD200R) by the widely distributed CD200. In the absence of CD200, animals display increased susceptibility to autoimmunity and earlier onset aggressive autoimmune disease… (More)

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@article{Copland2007MonoclonalAC, title={Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis.}, author={David A. Copland and Claudia Jane Calder and Ben J. E. Raveney and Lindsay B. Nicholson and Joseph Phillips and Holly M Cherwinski and Maria Christina Jenmalm and Jonathon D. Sedgwick and Andrew David Dick}, journal={The American journal of pathology}, year={2007}, volume={171 2}, pages={580-8} }