Monoclonal antibody mechanisms of action in cancer.

  title={Monoclonal antibody mechanisms of action in cancer.},
  author={George J Weiner},
  journal={Immunologic research},
  volume={39 1-3},
Monoclonal antibodies (mAbs) are used extensively as treatment for cancer. A variety of mechanisms are thought to play important roles in mediating the observed anti-tumor effects of mAb. These include signaling mediated by cross-linking of surface antigen that leads to cell death, blocking an activation signal that is necessary for continued cell growth, antibody-dependent cellular cytotoxicity (ADCC), complement mediated cytotoxicity (CMC) and the ability of mAb to alter the cytokine milieu… CONTINUE READING
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