Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes.

@article{Song1985MonoclonalAR,
  title={Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes.},
  author={Byoung Joo Song and H. V. Gelboin and S. S. Park and George C Tsokos and Fred K. Friedman},
  journal={Science},
  year={1985},
  volume={228 4698},
  pages={490-2}
}
A multiplicity of cytochromes P-450 is responsible for the detoxification and activation of xenobiotics such as drugs and carcinogens. Individual differences in sensitivity to these agents may reside in the cytochrome P-450 phenotype. A monoclonal antibody-directed radioimmunoassay was developed that detects epitope-specific cytochromes P-450 in human placentas and peripheral lymphocytes. Placentas from women who smoked cigarettes contained greater amounts of cytochrome P-450 with the… CONTINUE READING

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