Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion.

@article{Katsuragawa1997MonoclonalAA,
  title={Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion.},
  author={H Katsuragawa and Hideharu Kanzaki and Takuya Inoue and Takeshi Hirano and Takahide Mori and Neal S. Rote},
  journal={Biology of reproduction},
  year={1997},
  volume={56 1},
  pages={50-8}
}
Naturally occurring antiphospholipid (aPL) antibodies against cardiolipin (CL)- and phosphatidylserine (PS)-dependent antigens are associated with placental dysfunction and unsuccessful pregnancy. Murine monoclonal aPL antibodies react with placental trophoblast and may interfere with normal trophoblastic function. In this study, we evaluated the expression of phospholipid-dependent antigens during trophoblast differentiation and measured the effects of monoclonal aPL antibodies on two in vitro… CONTINUE READING
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