Monoclonal antibody against human Tim-3 enhances antiviral immune response.

@article{Li2019MonoclonalAA,
  title={Monoclonal antibody against human Tim-3 enhances antiviral immune response.},
  author={Ge Li and Chunmei Hou and Shuaijie Dou and Jiacheng Zhang and Yanling Zhang and Yiqiong Liu and Zhiding Wang and He Xiao and Robert K. Wang and G M Chen and Yan Li and Jiannan Feng and Beifen Shen and Gencheng Han},
  journal={Scandinavian journal of immunology},
  year={2019},
  volume={89 2},
  pages={
          e12738
        }
}
T cell immunoglobulin and mucin domain protein 3 (Tim-3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim-3 is related to immune exhaustion in tumour and viral infection. To overcome Tim-3-mediated immune tolerance, we developed a novel monoclonal antibody against human Tim-3 (L3G) and investigated its roles in inhibiting Tim-3 signalling and overcoming immune tolerance in T cells and monocytes/macrophages. The administration of L3G to… CONTINUE READING
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