Monoclonal antibody against a 52 K sperm surface protein inhibits sperm-zona pellucida interactions in the rat.

A major regulatory site for species specificity of fertilization in mammals lies at the level of sperm binding to the zona pellucida. This implies a high degree of complementarity between gamete and receptor molecules. These molecules support species-specific interactions between sperm and oocyte that lead to gamete fusion (fertilization). We identified a… CONTINUE READING