Monoclonal antibody C219 immunohistochemistry against P-glycoprotein: sequential analysis and predictive ability in dogs with lymphoma.

@article{Bergman1996MonoclonalAC,
  title={Monoclonal antibody C219 immunohistochemistry against P-glycoprotein: sequential analysis and predictive ability in dogs with lymphoma.},
  author={Philip J. Bergman and Gregory K. Ogilvie and Barbara E. Powers},
  journal={Journal of veterinary internal medicine},
  year={1996},
  volume={10 6},
  pages={354-9}
}
In the present study, the prevalence of positive staining for P-glycoprotein using C219 monoclonal antibody was assessed in 58 tissue samples of high-grade lymphoma from dogs before initiation of chemotherapy. Samples were also evaluated at relapse in 22 dogs, at necropsy in 34 dogs, and at all 3 times in 15 dogs. The frequency of positive staining was significantly higher than that found prior to the initiation of chemotherapy at the following times: relapse (P = .0001), necropsy (P < .0001… CONTINUE READING

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