Monoclonal antibodies to uveal melanoma

  title={Monoclonal antibodies to uveal melanoma},
  author={Bertil E. Damato and Allyson M Campbell and Brendon McGuire and W R Lee and Wallace S. Foulds},
Rat monoclonal antibodies were prepared against antigens expressed by uveal melanomas. Uncultured cells from primary human uveal melanomas were used for the rat inoculations and for the screening of hybridomas by enzyme-linked immunosorbent assay (ELISA). One of the monoclonal antibodies, designated 4A3, recognised a cytoplasmic antigen which was relatively specific for melanoma cells and which could be detected by immunohistochemistry in formalin-fixed, paraffin embedded tumour tissue. Western… CONTINUE READING
2 Extracted Citations
17 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 17 references

Hetero ­ geneous expression of melanoma - associated antigens in uveal melanomas

  • van der Pol lP, lager Ml, D deWolff-Rouendaal, Ringens Pl, C Vennegoor, Ruiter Dl
  • Current Eye Research
  • 1987

Monoclonal antibodies to human primary uveal melanomas demonstrate tumor heterogeneity

  • BE Damato, AM Campbell, McGuire Bl, WR Lee, WS Foulds
  • Invest Ophthalmol Vis Sci
  • 1986

Similar Papers

Loading similar papers…