Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages.

@article{Olsen1992MonoclonalAT,
  title={Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages.},
  author={Christopher W. Olsen and W V Corapi and Christopher K Ngichabe and Joel D. Baines and Fraser W. Scott},
  journal={Journal of virology},
  year={1992},
  volume={66 2},
  pages={956-65}
}
Antibody-dependent enhancement of virus infection is a process whereby virus-antibody complexes initiate infection of cells via Fc receptor-mediated endocytosis. We sought to investigate antibody-dependent enhancement of feline infectious peritonitis virus infection of primary feline peritoneal macrophages in vitro. Enhancement of infection was assessed, after indirect immunofluorescent-antibody labelling of infected cells, by determining the ratio between the number of cells infected in the… CONTINUE READING