Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

@article{Horton1985MonoclonalAT,
  title={Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.},
  author={Michael A. Horton and David B. Orlando Lewis and K. J. Mcnulty and Jean A. S. Pringle and Timothy John Chambers},
  journal={Cancer research},
  year={1985},
  volume={45 11 Pt 2},
  pages={
          5663-9
        }
}
The cellular origin of the osteoclast, the major agent of bone resorption, remains controversial despite the demonstration that osteoclasts form by fusion of mononuclear cells that are ultimately derived from a bone marrow stem cell. One view is that they are the terminally differentiated progeny of mononuclear phagocytic cells. However, we have previously provided evidence, from functional and phenotypic studies of rodent and human osteoclasts, that raises the possibility that osteoclasts form… CONTINUE READING

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