Monoclonal antibodies to equine interferon-alpha (IFN-alpha): new tools to neutralize IFN-activity and to detect secreted IFN-alpha.

@article{Wagner2008MonoclonalAT,
  title={Monoclonal antibodies to equine interferon-alpha (IFN-alpha): new tools to neutralize IFN-activity and to detect secreted IFN-alpha.},
  author={Bettina Wagner and Julie M. Hillegas and M. Julia B.F. Flaminio and Eva Wattrang},
  journal={Veterinary immunology and immunopathology},
  year={2008},
  volume={125 3-4},
  pages={
          315-25
        }
}
Interferon-alpha (IFN-alpha) is a type I interferon that is secreted during the early stages of the innate immune response and is often induced upon infection with viral pathogens. IFN-alpha production affects multiple downstream events influencing both innate and adaptive immune responses. Here, we describe the expression of an equine rIFN-alpha/IgG4 fusion protein in mammalian cells. The anti-viral activity of rIFN-alpha/IgG4 was found to be 70-fold higher than that of a previously described… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Molecular cloning and expression in Escherichia coli of equine type I interferons

  • A. Himmler, R. Hauptmann, R. A. Guenther, P. Swetly
  • DNA
  • 1986
Highly Influential
5 Excerpts

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