Monoclonal antibodies to cytomegalovirus: rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia.

@article{Goldstein1982MonoclonalAT,
  title={Monoclonal antibodies to cytomegalovirus: rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia.},
  author={L C Goldstein and J. McDougall and R. Hackman and James Meyers and E. Donnall Thomas and Robert C. Nowinski},
  journal={Infection and immunity},
  year={1982},
  volume={38 1},
  pages={273-81}
}
Two monoclonal antibodies which react specifically with cells infected by cytomegalovirus (CMV) are described. One antibody, 6-E3, reacts with a 72,000-dalton protein that appears early in infection and remains localized in the cell nucleus. The other antibody, 6-C5, reacts with an 80,000-dalton protein that appears late in infection and remains localized in cytoplasmic inclusion bodies. Both monoclonal antibodies react with conventional laboratory strains of CMV and can be used in… CONTINUE READING

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