Monoclonal antibodies to angiotensin-converting enzyme: a powerful tool for lung and vessel studies.

@article{Danilov1989MonoclonalAT,
  title={Monoclonal antibodies to angiotensin-converting enzyme: a powerful tool for lung and vessel studies.},
  author={Sergei M Danilov and Iu I Sakharov and Alexander V. Martynov and Alexander Faerman and Vladimir R Muzykantov and A A Klibanov and Ilya N. Trakht},
  journal={Journal of molecular and cellular cardiology},
  year={1989},
  volume={21 Suppl 1},
  pages={165-70}
}
We obtained a series (12 clones) of hybridomas, which produce monoclonal antibodies (Mab) to 5 different epitopes of the angiotensin-converting enzyme (ACE) molecule. These antibodies may be used to (1) map antigenic structure of ACE, including the study of immunologic heterogeneity of ACE from different organs and tissues; (2) study the immunohistochemical distribution of ACE in human tissues, including the diagnosis of sarcoidosis; (3) develop an ACE immunoassay, and (4) prepare an… CONTINUE READING