Monoclonal antibodies to a human prostate antigen.

  title={Monoclonal antibodies to a human prostate antigen.},
  author={Arthur Edward Frankel and Robert V. Rouse and M. C. Wang and T. Ming Chu and Leonard A. Herzenberg},
  journal={Cancer research},
  volume={42 9},
Three monoclonal antibodies reactive with a purified extractable Mr 34,000 prostate antigen (PA) have been prepared by fusing splenocytes of BALB/c mice preimmunized with purified PA with the NS1 mouse myeloma cell line. The three antibodies were all of the IgG-1 subclass. The antibodies defined two noncross-blocking unique determinants on PA; each present as one site per molecule. IF3 defined one antigenic site and 2G7 and 1C5 defined another antigenic determinant. All of the antibodies… CONTINUE READING


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