Monoclonal antibodies to a benzo[a]pyrene diolepoxide modified protein.

  title={Monoclonal antibodies to a benzo[a]pyrene diolepoxide modified protein.},
  author={Regina M. Santella and Chen Dong Lin and N Dharmaraja},
  volume={7 3},
Monoclonal antibodies have been developed which specifically recognize protein modified by 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I). These antibodies have been characterized as to sensitivity and specificity by an enzyme-linked immunosorbent assay. They react with BPDE-I-modified proteins and do not cross-react with non-modified protein. All the antibodies have higher sensitivity toward BPDE-I-tetraols than to BPDE-I-modified protein. They cross… CONTINUE READING

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