Monoclonal antibodies that detect different antigenic determinants of the same human osteosarcoma-associated antigen.

@article{Wada1988MonoclonalAT,
  title={Monoclonal antibodies that detect different antigenic determinants of the same human osteosarcoma-associated antigen.},
  author={Takuro Wada and Toshimitsu Uede and Shunsuke Ishii and Katsuhiko Matsuyama and Shinya Yamawaki and Kunimi Kikuchi},
  journal={Cancer research},
  year={1988},
  volume={48 8},
  pages={2273-9}
}
Monoclonal antibodies (MoAbs) against human osteosarcoma cells were obtained by the fusion of NS/1 mouse myeloma cells with spleen cells from the human osteosarcoma cell line-immunized BALB/c mice. Two hybrid clones were established and designated as 2H10 and 2D3. Both MoAbs reacted strongly with all osteosarcoma tissues but not with other bone and soft tissue tumors such as chondrosarcoma, malignant fibrous histiocytoma, liposarcoma, leiomyosarcoma, and rhabdomyosarcoma. In addition, neither… CONTINUE READING
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