Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75

@article{Sheehan1995MonoclonalAS,
  title={Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75},
  author={Kathleen C. F. Sheehan and J Keith Pinckard and Cora D. Arthur and Louis P. Dehner and David V. Goeddel and Robert D Schreiber},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={607 - 617}
}
Monoclonal antibodies (mAbs) specific for the murine p55 and p75 tumor necrosis factor (TNF) receptors were produced after immunization of Armenian hamsters with the purified soluble extracellular domains of each receptor protein. Four p55- (55R) and five p75 (TR75)-reactive mAbs immunoprecipitated the appropriate receptor from the surface of L929 cells. None of the mAbs cross-reacted with the other TNF receptor form. The mAbs were functionally characterized by their ability to inhibit ligand… CONTINUE READING

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References

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Showing 1-10 of 53 references

Decreased sensitivity to turnout - necrosis factor but normal T - ceU development in TNF receptor - 2 - deficient mice

  • R. D. Schreiber, E. R. Unanue
  • Nature ( Lond . ) .
  • 1994

Dissociation of TNF-c~ cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-ot mutants

  • A. J. Barbara, W. B. Smith, +6 authors A. F. Lopez
  • EMBO (Eur. Mol. Biol. Organ.)J
  • 1994
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