Monoclonal antibodies recognizing structural components of murine retroviruses including an FMR antigen on protein p12.

@article{Gambke1984MonoclonalAR,
  title={Monoclonal antibodies recognizing structural components of murine retroviruses including an FMR antigen on protein p12.},
  author={C. Gambke and H. Senn and G. Hunsmann and G. Schumann and C. Moroni and S. Alkan},
  journal={The Journal of general virology},
  year={1984},
  volume={65 ( Pt 9)},
  pages={
          1507-17
        }
}
Monoclonal antibodies were prepared from mice and rats immunized with Friend leukaemia virus and BALB/c xenotropic virus. By immunoprecipitation of 125I-labelled and [35S]methionine-labelled viruses and by protein blotting, ten antibodies were found to react with the viral components p12, p15, p30, gp70 and p15E/p12E. A dot-immunobinding assay was found to be a reliable method to type the antibody reactivity with different murine leukaemia viruses (MuLVs). When tested on a panel of ecotropic… Expand
3 Citations
Monoclonal antibodies to murine retrovirus protein p30.
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Hybrid cell lines prepared by the fusion of mouse myeloma cells with the spleen cells of Wistar-Furth rats that had been immunized with a Moloney sarcoma virus-induced tumour, MFU, found to recognize three non-overlapping epitopes on p30, the major core polypeptide of murine retroviruses. Expand
Syngeneic monoclonal antibodies directed against rauscher virusinduced myeloid leukemic cells: Isolation and characterization
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Since RMB‐1 cells do not produce virus, but express aberrant viral proteins, these MAbs are tumor‐specific and useful for immunotherapy, according to immuno‐electron microscopy. Expand
Immunotherapy in mice of virally induced tumors using syngeneic monoclonal antibodies
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This thesis deals with one variant of immunotherapy, namely the use of tumor-specific antibodies to induce tumor destruction in a disseminated tumor model and investigates the underlying mechanism, namely delayed-type hypersensitivity elicited by the tumor cells in the immunocompetent host. Expand

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