Monoclonal antibodies reacting with the MUC2 mucin core protein.

@article{Devine1993MonoclonalAR,
  title={Monoclonal antibodies reacting with the MUC2 mucin core protein.},
  author={P. L. Devine and Michael A McGuckin and Geoffrey W. Birrell and Robert H. Whitehead and Goverdhan P. Sachdev and P. Shield and Bruce G. Ward},
  journal={British Journal of Cancer},
  year={1993},
  volume={67},
  pages={1182 - 1188}
}
This study sought to produce monoclonal antibodies (MAbs) which reacted with the MUC2 core protein. Two MAbs [3A2 (IgG1) and 4F1 (IgM)] were produced by immunising female BALB/c mice with gel-formed mucin from the LS174T colon cancer cell line followed by a KLH conjugate of a 29 amino acid synthetic peptide whose sequence was derived from the variable number of tandem repeats (VNTR) region of a MUC2 cDNA clone. The MAbs reacted with synthetic MUC2 VNTR peptides but not synthetic MUC1 or MUC3… CONTINUE READING

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