Monoclonal antibodies labeled with polymeric paramagnetic ion chelates

  title={Monoclonal antibodies labeled with polymeric paramagnetic ion chelates},
  author={P. Shreve and A. Aisen},
  journal={Magnetic Resonance in Medicine},
  • P. Shreve, A. Aisen
  • Published 1986
  • Chemistry, Medicine
  • Magnetic Resonance in Medicine
  • Polymeric paramagnetic ion chelate molecules were synthesized and covalently linked to monoclonal antibodies. The labeled antibodies retained their antigen binding capacity in vitro while carrying up to an average of 50 paramagnetic ion chelates, enabling specifically bound antibody concentrations less than 2.0 μM to significantly reduce proton longitudinal relaxation times. © 1986 Academic Press, Inc. 

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