Monoclonal antibodies inhibit prion replication and delay the development of prion disease

@article{White2003MonoclonalAI,
  title={Monoclonal antibodies inhibit prion replication and delay the development of prion disease},
  author={Anthony R White and Perry Enever and Mourad Tayebi and Rosey E Mushens and Jackie Linehan and Sebastian Brandner and David J Anstee and John Collinge and Simon Hawke},
  journal={Nature},
  year={2003},
  volume={422},
  pages={80-83}
}
Prion diseases such as Creutzfeldt–Jakob disease (CJD) are fatal, neuro-degenerative disorders with no known therapy. A proportion of the UK population has been exposed to a bovine spongiform encephalopathy-like prion strain and are at risk of developing variant CJD. A hallmark of prion disease is the transformation of normal cellular prion protein (PrPC) into an infectious disease-associated isoform, PrPSc. Recent in vitro studies indicate that anti-PrP monoclonal antibodies with little or no… CONTINUE READING
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