Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells

@article{Borsi1987MonoclonalAI,
  title={Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells},
  author={Laura Borsi and Barbara Carnemolla and Patrizia Castellani and C Rosellini and Darleen Vecchio and Giorgio Allemanni and S. Ernest Chang and Joyce Taylor-Papadimitriou and H. Pande and Luciano Zardi},
  journal={The Journal of Cell Biology},
  year={1987},
  volume={104},
  pages={595 - 600}
}
Recent results showing that a single fibronectin gene can give rise to several different mRNAs by alternative splicing have offered an explanation for fibronectin polymorphism. Here we report on monoclonal antibodies that show specificity for a fibronectin segment (ED) that can be included or omitted from the molecule depending on the pattern of splicing of the mRNA precursors. Using these monoclonals, we have quantitatively analyzed the expression of the ED sequence in human fibronectin from… CONTINUE READING
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