Monoclonal antibodies in acute lymphoblastic leukemia.

@article{Jabbour2015MonoclonalAI,
  title={Monoclonal antibodies in acute lymphoblastic leukemia.},
  author={Elias J Jabbour and Susan M O'Brien and Farhad Ravandi and Hagop M Kantarjian},
  journal={Blood},
  year={2015},
  volume={125 26},
  pages={4010-6}
}
With modern intensive combination polychemotherapy, the complete response (CR) rate in adults with acute lymphoblastic leukemia (ALL) is 80% to 90%, and the cure rate is 40% to 50%. Hence, there is a need to develop effective salvage therapies and combine novel agents with standard effective chemotherapy. ALL leukemic cells express several surface antigens amenable to target therapies, including CD20, CD22, and CD19. Monoclonal antibodies target these leukemic surface antigens selectively and… CONTINUE READING
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