Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.

@article{Kintner1984MonoclonalAI,
  title={Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.},
  author={Chris Kintner and Jeremy P. Brockes},
  journal={Nature},
  year={1984},
  volume={308 5954},
  pages={67-9}
}
Blastemal cells arise after the amputation of limbs or tails in urodele amphibians. These histologically undifferentiated mesenchymal cells divide and subsequently differentiate to regenerate a new appendage. Various studies (reviewed in ref. 1) indicate that blastemal cells arise from tissues near the site of amputation, including muscle, cartilage, nerve… CONTINUE READING