Monoclonal antibodies directed to chemically synthesized lactogangliotetraosylceramide, a leukemia-associated antigen having a novel branching structure.

@article{Shigeta1987MonoclonalAD,
  title={Monoclonal antibodies directed to chemically synthesized lactogangliotetraosylceramide, a leukemia-associated antigen having a novel branching structure.},
  author={Katsuyoshi Shigeta and Y. N. Ito and Tomoya Ogawa and Yuka Kirihata and Sen‐itiroh Hakomori and Reiji Kannagi},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 3},
  pages={
          1358-62
        }
}
1H NMR studies of a biosynthetic lacto-ganglio hybrid glycosphingolipid: confirmation of structure, interpretation of "anomalous" chemical shifts, and evidence for interresidue amide-amide hydrogen bonding.
TLDR
An approximate three-dimensional structure for LcGg4Cer is proposed, consistent with all data obtained, which should be useful in discussing the results of 1H NMR analysis of compounds containing this core tetrasaccharide.
Gangliosides and sialoglycoproteins carrying a rare blood group antigen determinant, Cad, associated with human cancers as detected by specific monoclonal antibodies.
TLDR
It was revealed that many cultured human hepatocellular carcinoma cell lines and cancer tissues taken from patients with hepato Cell carcinoma contain both Cad-active glycoprotein antigens and related gangliosides, while normal liver tissues contain no appreciable amount of either species of antigen.
Monoclonal antibodies directed to a disulfated glycosphingolipid, SB1a (GgOse4Cer-II3IV3-bis-sulfate), associated with human hepatocellular carcinoma.
TLDR
Results strongly suggest that the SB1a antigen as defined by these new monoclonal antibodies is associated with human hepatocellular carcinoma.
A monoclonal antibody to free N-acetylneuraminic acid.
Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM2 gangliosides.
TLDR
Investigation of the glycolipid preparations extracted from the cancer tissues of 39 patients with lung cancer showed that the N-acetyl GM2 was present not only in small cell carcinoma tissues as one of the antigens related to tumors of neuroectodermal origin, but also in the squamouscell carcinoma and adenocarcinoma of the lung with a comparable frequency.
Establishment and Characterization of a Mouse Monoclonal Anti-Fucosylceramide Antibody , PC 47 H
TLDR
A novel mouse monoclonal anti-fucosylceramide antibody was created by using neutral glycolipids from a human pancreas cancer tissue as the immunogen and showed that the antigen specificity of PC47H was exclusively directed against fuco sylceramide.
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