Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration.

@article{Highlander1988MonoclonalAD,
  title={Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration.},
  author={S L Highlander and Wenyi Cai and Stanley Person and Michael Levine and Joseph Charles Glorioso},
  journal={Journal of virology},
  year={1988},
  volume={62 6},
  pages={1881-8}
}
In an earlier report (S.D. Marlin, S.L. Highlander, T.C. Holland, M. Levine, and J.C. Glorioso, J. Virol. 59: 142-153), we described the production and use of complement-dependent virus-neutralizing monoclonal antibodies (MAbs) and MAb-resistant (mar) mutants to identify five antigenic sites (I to V) on herpes simplex virus type 1 glycoprotein B (gB). In the present study, the mechanism of virus neutralization was determined for a MAb specific for site III (B4), the only site recognized by MAbs… CONTINUE READING

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