Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion.

@article{Epstein1981MonoclonalAA,
  title={Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion.},
  author={Norman Epstein and Louis H. Miller and D C Kaushel and Iroka J. Udeinya and Joan C. Rener and Russell John Howard and Richard Asofsky and Masamichi Aikawa and Robert Lawrence Hess},
  journal={Journal of immunology},
  year={1981},
  volume={127 1},
  pages={
          212-7
        }
}
Twelve hybridoma cell lines secreting monoclonal antibodies against Plasmodium knowlesi merozoites have been produced. Antibodies from 3 of the 12 lines agglutinated merozoites. The 2 monoclonal antibodies (13C11 and 16F8) that markedly agglutinated merozoites blocked merozoite invasion of erythrocytes. Of these 2 lines, the one that induced the most agglutination also blocked invasion most effectively. The third monoclonal antibody (53B3) caused minimal agglutination of merozoites and did not… CONTINUE READING

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