Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells

@article{Daneshmanesh2012MonoclonalAA,
  title={Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells},
  author={Amir Hossein Daneshmanesh and Mohammad Hojjat-Farsangi and Abdul Salam Khan and Mahmoud Jeddi-Tehrani and Mohammad Mehdi Akhondi and Ali Ahmad Bayat and Roya Ghods and A Mahmoudi and Reza Hadavi and Anders {\"O}sterborg and F Askari Seyed Shokri and Hodjattallah Rabbani and H{\aa}kan Mellstedt},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={1348-1355}
}
ROR1 is a receptor tyrosine kinase (RTK) recently identified to be overexpressed at the gene and protein levels in chronic lymphocytic leukemia (CLL). Monoclonal antibodies (MAbs) against RTKs have been successfully applied for therapy of solid tumors. We generated five MAbs against the Ig (n=1), cysteine-rich (CRD) (n=2) and kringle (KNG) (n=2) domains, respectively, of the extracellular part of ROR1. All CLL patients (n=20) expressed ROR1 on the surface of the leukemic cells. A significantly… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy.

  • Expert opinion on therapeutic targets
  • 2015
VIEW 7 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Nutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2011

Management Guidelines for the Use of Alemtuzumab in Chronic Lymphocytic Leukemia

A. Oesterborg, Robin Foà, +7 authors Clemens-Martin Wendtner
  • 2010