Monoclonal antibodies against LDL progressively oxidized by myeloperoxidase react with ApoB-100 protein moiety and human atherosclerotic lesions.

@article{Moguilevsky2004MonoclonalAA,
  title={Monoclonal antibodies against LDL progressively oxidized by myeloperoxidase react with ApoB-100 protein moiety and human atherosclerotic lesions.},
  author={Nicole Moguilevsky and Karim Zouaoui Boudjeltia and Sajida Babar and Paul Delr{\'e}e and Ilham Legssyer and Yves Carpentier and Michel Vanhaeverbeek and Jean Ducobu},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={323 4},
  pages={1223-8}
}
Oxidized-LDL are involved in atherosclerosis pathogenesis, while the production of anti-ox-LDL monoclonal antibodies is critical for the development of diagnostic tools. This work reports the production of four monoclonal antibodies raised against human LDL, oxidized at different levels by the myeloperoxidase system. Characterization of these monoclonal antibodies showed that they do not cross-react with neither native LDL, VLDL nor hydrogen peroxide or Cu(2+)-oxidized LDL. Three of these… CONTINUE READING