Monoclonal antibodies against HIV type 1 integrase: clues to molecular structure.

@article{BizubBender1994MonoclonalAA,
  title={Monoclonal antibodies against HIV type 1 integrase: clues to molecular structure.},
  author={D Bizub-Bender and Joseph Kulkosky and Anna Marie Ann Skalka},
  journal={AIDS research and human retroviruses},
  year={1994},
  volume={10 9},
  pages={1105-15}
}
Eleven murine hybridoma clones were selected for their ability to produce anti-HIV-1 integrase (IN) antibodies. Competition and epitope mapping studies allowed segregation of the monoclonal antibodies (MAbs) into four distinct classes. The five MAbs that comprise the first class showed high affinity for epitopes within an N-terminal domain of 58 amino acids that includes a conserved zinc finger motif. The second class, with two MAbs, showed high affinity for epitopes within 29 amino acids at… CONTINUE READING

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