Monoclonal antibodies against Epstein–Barr virus cross-react with α-synuclein in human brain

@article{Woulfe2000MonoclonalAA,
  title={Monoclonal antibodies against Epstein–Barr virus cross-react with $\alpha$-synuclein in human brain},
  author={John Woulfe and Hugh Hoogendoorn and Mark A. Tarnopolsky and Diego Mu{\~n}oz},
  journal={Neurology},
  year={2000},
  volume={55},
  pages={1398 - 1401}
}
Article abstract Using antibodies generated against the latent membrane protein 1 of Epstein–Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity… Expand

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