Monoclonal anti-parathyroid antibodies interfering with a Ca2+-sensor of human parathyroid cells.

Abstract

Previous findings indicate that binding of Ca2+ to an external receptor is part of the mechanism by which extracellular Ca2+ regulates cytoplasmic Ca2+ and hormone release of parathyroid cells. We now present evidence that two newly generated monoclonal anti-parathyroid antibodies react with structures involved in this sensing and/or gating of Ca2… (More)

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