Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance

@article{Ducong2002MonoclonalAA,
  title={Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance},
  author={Jorge Ducong{\'e} and Eduardo M Fern{\'a}ndez-S{\'a}nchez and Alfonso Guti{\'e}rrez Mac{\'i}as and Rub{\'e}n Mart{\'i}nez Castillo and Israel Oliver Garc{\'i}a and Irene Beausoleil and Jorge Isaac Cardoza Amador and Janet Matheu},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2002},
  volume={27},
  pages={101-105}
}
SummaryWith the purpose of describing the MAb ior-R3’s kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H125) bearing nude mice animal model. This MAb was administered by a single 16 mg/Kg intravenous bolus dose and the blood samples were collected at several times ranging from 0 to 72 hours for serum drug quantification. The experimental data set was best fitted using a classical two-compartment mammilary… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 12 REFERENCES

Monoclonal anti - egfr ( iior r 3 ) antibody ' s pharmacokinetic studies on nude mice : a radio receptor analysis applied to serum drug quanntification

E. FernandezSanchez, J. Duconge, R. Castillo, Beausoleil 1. Garcia 1., A Macias
  • Journal of Pharmacy and Pharmacology
  • 2002

Endocytosis of Lisosomal Targeting of EGFr are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domains

Opresko, CK, +5 authors H. S. Wiley
  • J. BioI. Chern
  • 1995

The dependence of the endocytosis of the EGFr on degree of receptor

Blagoveshchenskaia, AD, I. Sokolova, E. Kornilova, N. N. Nioliski
  • occupancy. Tsitologia
  • 1994

The dependence of the endocytosis of the EGFr on degree of receptor occupancy

AD. Blagoveshchenskaia, I. Sokolova, E. Kornilova, N. N. Nioliski
  • Tsitologia
  • 1994

The case for preclinical pharmacodynamics

G. Levy
  • 1993

Innovation that Influence the Pharmacology of Monoclonal antibody Guided Tumour Targetting

J. Schlom, P. Horan-Hand, +8 authors A. Raubitschek
  • Cancer Research
  • 1990