Monoclonal anti-D antibodies to prevent alloimmunization: lessons from clinical trials.

  title={Monoclonal anti-D antibodies to prevent alloimmunization: lessons from clinical trials.},
  author={Roland B{\'e}liard},
  journal={Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine},
  volume={13 1-2},
  • Roland Béliard
  • Published 2006 in
    Transfusion clinique et biologique : journal de…
In the past 20 years, numerous monoclonal anti-D antibodies have been developed in order to replace the human plasma derived anti-D immunoglobulins, using different in vitro functional assays as screening methods. Some of these monoclonal antibodies have been evaluated in exploratory in vivo clinical trials, notably for their ability to mediate the clearance of D-positive red cells. A review of these reported trials is presented and the results are analyzed in the light of the newly published… CONTINUE READING

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